Antibiotic resistance is day by day becoming greater health concern. Tremendous use of antibiotic in poultry is known to be a major cause for antibiotic resistant in human. An experiment of meat samples was purchased from various meat shops and examined for bacterial contamination with resistant E. coli. (Total=384) Samples were taken for the study and among them, 189 isolates were evaluated for their antibiotic susceptibilities and the presence of antibiotic resistance. Results of antibiograms revealed that E. coli isolates were resistant to one or more of the antibiotics tested. Ciprofloxacin (42.32%) is higher resistance from the for-E. coli. Colistin Sulphate (2.11%) is less resistance for E. Coli. Whereas Chroramphenicol (42.32%), Gentamicin (41.79%), Levofloxacin (34.92%), Amikamicin (7.4%), resistance was most frequently observed. Fifteen E. coli strains showed the multidrug resistance phenotypes and harbour at least three antibiotic resistances. The results indicated that production methods influenced the frequency of antibiotic resistant E. coli on poultry products available to consumers. Future research to identify the specific practices that cause the high frequency of antibiotic-resistant E. coli in chicken could promote efforts to reduce consumer exposure to this potential pathogen.